Frits Goedegebuur
DuPont Industrial Biosciences, The Netherlands
Title: IPE - Industrial protein engineering: Accelerated evolution
Biography
Biography: Frits Goedegebuur
Abstract
Historically, the protein design process has been approached as equivalent to the problem of finding in all of protein space the one best sequence for a single property. For accelerated evolution, the problem to be solved is to identify at least one protein sequence that meets or exceeds the minimum value required for a number of properties. Protein engineered proteins came about through accumulation of point mutations that were not deleterious for any important property. Using the “Super-screen†process, we can determine all those mutations in a matter of weeks for any protein for all important properties. Combining these mutations in the proper way can rapidly produce a protein with all desired properties.
