Genetic and Protein Engineering

Ubiquinone (coenzyme Q) is the kinds of compound which are classified into the type of lipid soluble quinone from the structure. Th ey have different structures because of the number of isoprenes present. We can know some research information about CoQ0, CoQ1, CoQ2, CoQ6, CoQ7, CoQ8, CoQ9, CoQ10 which has been synthesized or extracted from the plants by the way of chemical synthesis. However, the method of chemosynthesis has the limited efficiency and higher cost during the course of procedure; in addition, for the extraction from the natural medicine, the same problem exists. Therefore,with the development of genomics and microbiome technology, more and more chemistry can be induced and extracted from the diverse biological creature or microzyme for the intrinsic mechanism which is found by the international scientists.Coenzyme Q exists in three redox forms, fully oxidized (ubiquinone), semiquinone radical (ubisemiquinone) and fully reduced (ubiquinol). In addition, coenzyme Q can form micellar aggregates while working with together in cell-free system; however, in the living cell, coenzyme can dissolve in lipid bilayers and bound to proteins. Coenzyme Q is the center and an essential component of the mitochondrial electron transport chain. Coenzyme Q can closely combine with the protein in the respiratory chain to have the action from the intrinsic mechanism. So from the in vivo and in vitro studies, coenzyme Q has important applications in the study of pharmacology & clinics; such as, treating cardiovascular diseases, Parkinson’s disease and Huntington’s disease, etc. I would like to give the presentation in the review of the preparation and application of coenzyme Q in order to be supported by the experts and professors who are always interested in the study on the relative area and give us better opinions or investment on the research projects.