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Stephen D Kirby


Stephen D Kirby

U.S. Army Medical Research Institute of Chemical Defense, USA

Biography

Stephen D Kirby has been working in the field of chemical threats for the US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Grounds for 30 years, to include areas of research such as cyanide detoxification, sulfur mustard metabolism, and edemagenic pulmonary threats. The focus of his current research area has been developing and evaluating catalytic and stoichiometric protein bioscavengers for organophosphorus compounds. Current research has investigated enzyme platforms that include human carboxylesterase, human paraoxonase-1, platelet activating factor acetylhydrolase and the bacterial enzyme phosphotriesterase.

Abstract

Abstract : A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman