4^th International Conference on Protein Engineering July 13-14, 2020 Helsinki, Finland

Track 1: Protein Engineering

The conception and production of unnatural polypeptides, often through modification of amino acid sequences that are found in nature is protein engineering. The structures and functions of synthetic protein can now be designed entirely on a computer or produced through directed evolution in the laboratory.

• Protein engineering design and selection
• In vitro evolution of proteins
• Advances in engineering proteins for biocatalysis
• Constructing functional biocatalysts
• Aspects of biocatalysis
• Growth of synthetic biology
• Protein folding
• Membrane proteins
• Plant and Human Genetics
• Retrometabolic drug design
• Computational protein engineering

Track 2: Genetic Engineering

Genetic adjustment also called Genetic engineering, is the immediate control of a living beings genome utilizing biotechnology. It is an arrangement of innovations used to change the genetic makeup of cells, comprising the exchange of genes within and across species boundaries to produce improved or novel organisms. The diverse points secured under genetic engineering are Genetic adjustment, Genome investigation, Genetic designing strategies, Molecular docking & computational transformative science.

• Genetic modification
• Molecular docking and computational evolutionary biology
• Applications of genomics
• Genome analysis
• Genetic engineering techniques
• Machine learning in molecular systems biology
• Current challenges in modeling cellular metabolism
• Plant Biotechnology, Plant Genetics and its developments
• Molecular Genetics and Microbiology
• Plant and Human Genetics
• Genetic and molecular basis of crop improvement
• Molecular Markers
• Transgenics

Track 3 : Enzyme Engineering

The application of genetic engineering techniques to enzyme technology is Enzyme engineering. Genetic engineering may be improved or altered through number of properties including the production and kinetics of the enzyme, structure of the enzymes, Structure of the enzymes, De novo design, Intersection of protein engineering and next-generation sequencing, Rational alteration of enzyme function, Combinatorial Enzyme Engineering & Enzyme and biosensor Engineering.

• Structure of the enzymes
• De novo design
• Intersection of protein engineering and next-generation sequencing
• Rational alteration of enzyme function
• Combinatorial enzyme engineering
• Enzyme and biosensor Engineering

Track 4: Structure and Function of Proteins

The three-dimensional arrangement of atoms in an amino acid-chain molecule is Protein structure. Polymers are proteins which specifically polypeptides and are formed from sequences of amino acids, and monomers of the polymer.

• Protein structure databases
• Protein Sequence Analysis
• Protein structure determination
• Protein folding

In many crucial biological processes and functions ,proteins play an important role They have many different functions in the body and are very versatile as listed below.

• Act as catalysts
• Transport other molecules
• Store other molecules
• Provide mechanical support
• Provide immune protection
• Generate movement
• Transmit nerve impulses
• Control cell growth and differentiation

The structure of proteins has an impact on their function to the extent is shown by the effect of changes in the structure of a protein. Including slight changes in the folding and shape of the protein may render it non-functional when any change in  protein at  any structural level.

Track 5: Genomics & Structural Genomics

The study of organism whole genomes and incorporating elements from genetics is Genomics. A combination of recombinant DNA, DNA sequencing  methods, and bioinformatics to sequence, assemble, and analyse the structure and function of genomes is used by Genomics.

•  Molecular and biomedical genetics
• Functional genomics
• Structural genomics
• Epigenomics

The field of genomics that involves the characterization of genome structures is Structural genomics. The practice of manipulating the genes and DNA segments of a species can be useful in this knowledge.

• Modelling Threading
• Structure databases
• Structural bioinformatics
• Traditional structural prediction

Track 6:  Protein Engineered Biomaterials

Modern techniques includes recombinant signaling molecules, scaffolds of solid free form fabrication, synthetic cartilage, electrochemical deposition, spinal fusion and ossification are new generated techniques for tissue engineering applications with the growth factors availability and the increasing knowledge base concerning the bone generation.The foremost research which includes Nano applications to biomedical sciences and tissue engineering, Nano medicines, Cell interactions with Nano particles, Revolutionary opportunities and future possibility of nanotechnology, Bio-nanotechnology Biomedical Nanotechnology, Tissue Growing Nanostructures, Nano-Mechanisms for Molecular Systems, Nano-Bio-Computing, Biomedical Application of Nanoparticles and Functional Nanomaterials and Devices for Biomedical Engineering Research.

• Biomaterials in biomedical engineering
• Protein-biomaterial interactions
• Biomaterials design and technology

Track 7: Proteomics in Plant & Animal

Each living cell in proteome is dynamic, altering in response to the metabolic state and reception of intracellular and extracellular signal molecules of the individual cell. Many of the proteins which are expressed will be post-translationally altered. Thus the purpose of the proteome analysis is to aid the understanding and interaction of the protein function, then it is the identification of the proteins in their final state which is required. The essential of Individual proteins is by mass spectrometric identification, indicating site and nature of medication.

• Gel based proteomics
• Shotgun proteomics
• Salinity Tolerance
• Photosynthesis
• Late-Embryogenesis Abundant (LEA) Proteins

Track 8: Pharmacogenomics & Pharmacoproteomics

The study of the genome role in drug response is Pharmacogenomics. The combination of pharmacology and genomics reflects its name. The genetic makeup of an individual affects response to drugs is analysed by Pharmacogenomics.

• Drug-metabolizing enzymes
• Predictive prescribing
• Clinical implementation
• Polypharmacy

Rapid advancing field is Pharmacoproteomics in which the techniques of proteomics are applied to develop pharmaceutical agents. Personalized medicine plays a major role in this branch of study. Proteomics being the full complement of proteins expresses by an organism or tissue under specified conditions at a specified time.The effect of disease or drugs can substitute for much more complex assays in pharmacodynamics at a lower cost in time,financial output,and clinical risk in the study is the full set of proteins usage.

Track 9: Mass Spectrometry in Proteome Research

The utilization of mass spectrometry to the study of proteins is Protein mass spectrometry. Characterization of proteins is the important emerging method for Mass spectrometry.  Cellular protein maps generation can be used in two-dimensional gel electrophoresis which give a quantitative and qualitative picture of the proteome. The method of choice for the rapid large-scale identification of these proteomes and their alterations is mass spectrometry. The mass spectrometry data to experimentally validate gene products and to assist in the process of genome annotation and comparison is used in Proteogenomics.

• Electrospray ionization mass spectrometry (ESI-MS)
• Matrix-Assisted laser desorption (MALDI-TOF-MS)
• Liquid chromatography mass spectrometry (LC-MS)
• Multidimensional protein identification technology
• Protein identification and validation

Track 10: Transcriptome analysis & Gene Expression

The first and important topics to be discussed is Transcriptome and gene expression. It can be achieved by gaining proper knowledge about functioning of mRNA, tRNA and rRNA. Subset of relevant target genes can be focused in Gene expression analysis experimentations. Through Sequence mapping, the location of gene and relative distances between genes on a chromosome can be determined. Transcriptome can be created using de novo transcriptome assembly method even in the lack of reference genome.

• Transcriptomes of stem cells and cancer cells
• The role of micro RNA (mi RNA) and small interfering RNA ( si RNA)
• Functioning of mRNA, tRNA and rRNA
• Cellular differentiation and carcinogenesis
• Serial analysis of gene expression
• Transcriptomic and proteomic profiling
• Transcription of gene

Track 11: Protein Biochemistry

The one of the chief classes of molecules studied in biochemistry and primary constituent of living things are Proteins. It provides the cell molecular machinery the most. Many are the enzymes or enzymes subunits. The struts form and joints of the cytoskeleton plays structural or mechanical roles in other proteins. The linear polymers in each protein is built of amino acids.

• Biochemistry of Metabolic syndromes
• Clinical gene therapy
• Nucleic acid based diagnosis
• Phytochemicals

Track 12 : Antibody Drug Therapy

The  human antibody gene libraries and synthetic antibody libraries are also prominent subject in Antibody Engineering. Antibody Engineering is a field which fueled by Engineering bi-specific antibodies, phage and yeast display of antibodies, Bi-specific antibodies and combination therapy and antibodies for cancer therapy. They are exclusive in their specificity and high affinity for a binding paper, it is a quality that has made them one of the most useful molecules for biotechnology and biomedical applications.

• Engineering bi-specific antibodies
• Phage and yeast display of antibodies
• Bi specific antibodies & combination therapy
• Antibodies for cancer therapy
• Human antibody gene libraries
• Synthetic antibody libraries

Track 13: Protein Therapeutics & Market Analysis

The various applications and sources for Protein Therapeutics & Market Analysis are Protein Biomarkers, Recombinant protein drugs, Protein gold standards, Protein expression services and market analysis, Fusion protein therapeutics. It has a significant role in almost every field of medicine, but this role is still only in its infancy.

• Protein Biomarkers and its Diagnostics
• Recombinant protein drugs
• Protein gold standards
• Protein expression services and market analysis
• Fusion protein therapeutics

Track 14: Molecular Modelling and Drug Designing

Medical chemists has become a valuable and essential tool to Molecular modelling in drug design process. Molecules of three-dimensional structures in the generation, manipulation or representation and associated physio-chemical properties is designated in the molecular modelling.

• Molecular Modelling: Principles And Applications
• Molecular graphics
• Monte Carlo method and Molecular design software
• Drug development
• Retrometabolic drug design

Track 15: Bioinformatics and Computational Biology

The computational methods developments and applications are useful to analyse biological data like genetic sequences, protein samples or cell populations, developing new predictions or discovery of new biology which is an interdisciplinary field in bio informatics and computational biology. Analytical methods, mathematical modeling and simulation is used in computational methods.

• Data mining and Machine Learning
• Computational anatomy
• Artificial Intelligence
• Computational biomodelling

Track 16: Applications of Genetic and Protein Engineering

Mostly we are having good research and number of companies and projects and there are lot of applications used for protein like protein identification and validation, Protein modification, targeting and degradation, imaging mass spectrometry and profiling of tissue sections, protein profiling studies in diabetes, designer proteins and protein dietary supplements.

• Protein identification and validation
• Protein modification, targeting and degradation
• Chemical genetic methodology
• ECM proteins and protein fragments
• Advances in cell and gene therapy
• Novel methods in regenerative medicine
• Molecular Breeding for sustainable Agriculture
• Plant Breeding

Track 17: Machine Learning Applications in Bioinformatics

The development of algorithms that learned by making predictions based on data and has number of applications emerging in the field of bioinformatics in a computer science subfield is Machine learning. The computational and mathematical approaches for understanding and processing biological data was dealed by Bioinformatics.

• Microarrays
• Stroke Diagnosis
• Text mining

MARKET ANALYSIS OF  PROTEIN ENGINEERING:

Protein Engg Meet 2020 is the great opportunity for researchers working with the new innovative techniques and researches in Protein Engineering. The process for the development of new proteins through directed evaluation and rational protein designing, which can be used as therapeutic agents is protein engineering. The arena of proteomics and nanotechnology development globally, rising incidences of chronic and autoimmune diseases, rise in the awareness among people regarding protein engineering, increasing focus on research and development process, development in drug delivery system, and in protein-based drugs of adoption rised over non-protein-based drugs are the prime growth drivers of protein engineering market. In protein engineering and its maintenance, higher cost of the research and development, higher cost of tools and instruments were used and complex government approval processes are the key restraints for protein engineering market.

Market Overview

In the agrochemical industry, Protein engineering holds an immense opportunity as engineering in proteins may lead to the generation of enzymes with improved function that may increase the crop yield or facilitate the biofuel production. A tool to attain increased crop yield needed to meet future demand is also likely to be played as an important role. The prevalence increasing of protein deficient diseases, adoption of protein drugs over non-protein drugs, demand for alternatives to chemical processes, and rising government funding for protein engineering are the propelling factors in the global protein engineering market.

A group of disorders that includes marasmus, kwashiorkor is Protein energy malnutrition (PEM). It is increasing in the rural areas of emerging economies. The protein deficient diseases is driving the overall market by increasing. The government initiatives is rising in number such as funding R&D for protein engineering and awareness programs, which have influenced the healthcare industry. Thus, the government is proactively investing in many of the research. Protein Technologies Ltd (PTL) has received funding from the UK government’s technology Strategy Board for its innovative research in protein engineering.

Scope of the Report

The process by which novel proteins with desired properties are developed, and has grown enormously since past three decades is protein engineering. A wide range of proteins tailored to specific health, industry, medicine, research, and biotechnology applications in the past few years have successfully generated by Protein engineers. The manipulation of the structures of proteins to produce the desired properties, or the synthesis of proteins with particular structures is protein engineering as per the scope of report.

Market Report:

Market Value for Protein Engineering from the year 2016-2021: The demand for protein engineering has been increasing from year to year. The market of protein engineering is predicted to grow at a 6.2% CAGR between 2017- 2023.

U.S. protein engineering market by technology, 2014 - 2025 (USD Million)

Top Universities in Worldwide

• California Institute of Technology (Caltech)
• University of Oxford
• Stanford University
• Massachusetts Institute of Technology (MIT)
• Princeton University
• University of Cambridge
• University of California, Berkeley
• European Association of Pharma Biotechnology (EAPB)
• European Federation of Biotechnology  

Major Protein Engineering Societies

• The American Physiological Society
• American Society for Biochemistry and Molecular Biology
• American Society for Pharmacology and Experimental Therapeutics
• American Society for Investigative Pathology
• American Society for Nutrition
• The American Association of Immunologists
• American Association of Anatomists
• The Protein Society
• Society for Developmental Biology
• American Peptide Society
• Association of Biomolecular Resource Facilities
• The American Society for Bone and Mineral Research
• American Society for Clinical Investigation
• Society for the Study of Reproduction
• Teratology Society
• The Endocrine Society
• The American Society of Human Genetics
• Society for Gynecologic Investigation
• Environmental Mutagen Society
• International Society for Computational Biology
• American College of Sports Medicine

Worlds Major Protein Engineering Societies

• The Antibody Society
• African Society for Bioinformatics and Computational Biology
• Biochemical society
• Royal Society of Chemistry
• International Federation for Cell Biology
• Federation of American Societies for Experimental Biology
• Academy of Nutrition and Dietetics
• Atlanta dietetic association
• Institute for Electronics and Nanotechnology
• Georgia Institute of Technology
• College of Engineering
• Georgia State University

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