Antibody Engineering

Antibody engineering is a great tool for improving antibody functions and immunogenicity improvement. Engineered therapeutic antibodies are better for affinity maturation, specifically by improving on-rate of the antibody binding affinities. The need to overcome the immunogenicity problem of rodent antibodies in clinical practice has resulted in a plethora of strategies to isolate human antibodies. If human antibodies are to be used, then one would like to understand the basis by which different isotypes interact with host effector systems, and if possible, improve on nature by engineering in desirable modifications.

  • Engineering bi-specific antibodies
  • Phage and yeast display of antibodies
  • Bi specific antibodies & combination therapy
  • Antibodies for cancer therapy
  • Human antibody gene libraries
  • Synthetic antibody libraries

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